Volker Ast

This study shows that reverse cardiac remodeling is a constrained multicellular state with partial recovery of metabolic programs but persistent inflammatory-mitochondrial dysfunction, mediated by lymphatic-derived Reelin.

The paper identifies plasmacytoid dendritic cells (pDCs) in tumor-draining lymph nodes as a potential biomarker for predicting response to PD-L1 blockade therapy in melanoma.

The paper improves the MIPRIP method to identify common and cancer-type specific TERT regulators across 19 cancers using human and mouse regulatory networks.