Ashraf Yusuf Rangrez

This study identifies TRIM11 as a regulator of EWSR1::ATF1 stability in clear cell sarcoma, showing its depletion leads to metabolic rewiring and cell death, with PCK1 as a potential biomarker.

This study identifies FYCO1 as a regulator of autophagy that improves cardiac remodeling after myocardial infarction by enhancing autophagic flux and reducing inflammation.

This study shows that reverse cardiac remodeling is a constrained multicellular state with partial recovery of metabolic programs but persistent inflammatory-mitochondrial dysfunction, mediated by lymphatic-derived Reelin.

This study identifies TRIM24 as a chromatin regulator that suppresses inflammatory signaling in cardiomyocytes, preventing cardiac inflammation and heart failure progression.

This paper integrates bulk and single-cell transcriptomic data from 25 heart failure studies to identify conserved multicellular coordination patterns in cardiac remodeling.