Author

Olga Sirbu

Agency for Science, Technology and ResearchORCID 0009-0008-7503-0083Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1

Frequent Co-Authors

Kumar SelvarajooiD· 2 shared Alessandro GiulianiiD· 1 shared Brian Keith KennedyiD· 1 shared Diogo BarardoiD· 1 shared Gunjan Agarwal· 1 shared Jan GruberiD· 1 shared Kamil PabisiD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 13 mutual co-author links

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2 shared papersGenomics

Kumar SelvarajooORCID

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2 papers

Recent·Most cited

Genomicsnpj Systems Biology and ApplicationsPeer-reviewedAug 11, 2025

Understanding the Role of Toggle Genes in Chronic Lymphocytic Leukemia Proliferation

Olga Sirbu, Gunjan Agarwal, Alessandro Giuliani, Kumar Selvarajoo

The paper analyzes RNA-Seq data of CLL cells to identify toggle genes and temporal differentially expressed genes, showing their role in cell-state transitions and population plasticity.

2 citations

humanbulk RNA-seq

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BioinformaticseLifePeer-reviewedJun 23, 2023

A concerted increase in readthrough and intron retention drives transposon expression during aging and senescence

Kamil Pabis, Diogo Barardo, Olga Sirbu…·Brian Keith Kennedy

The paper shows that aging and senescence increase transposon expression through transcriptional readthrough and intron retention, not autonomous transposon activity.

22 citations

humanmouse

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