Brian Keith Kennedy

The paper shows copper and iron regulate cellular survival through distinct TORC1 and AMPK pathways in yeast under nutrient stress.

The paper investigates the relationship between fatty acid metabolism and cellular longevity by integrating interactome analyses, transcriptomics, and lifespan assays in human and yeast.

The paper identifies metabolic state transitions regulated by TORC1 that influence cellular aging in yeast and human cells.

This study shows mitochondrial competence determines cellular responses to metabolic interventions during aging, with TORC1 signaling and mitochondrial function being key factors.

This study maps metabolic changes in 12 organs of male and female mice across 5 ages, identifying sex-specific patterns and a metabolic aging clock.

This study introduces DoliClock, a lipid-based aging clock that identifies accelerated aging in neurological disorders like autism and schizophrenia.

The paper analyzes gut metagenomes of Asian octogenarians to identify age-related microbial shifts and their associations with aging phenotypes.

This study shows that reducing folate intake in aged mice decreases biosynthetic processes but does not compromise healthspan, suggesting age-dependent benefits of folate restriction.

The paper shows that aging and senescence increase transposon expression through transcriptional readthrough and intron retention, not autonomous transposon activity.

The paper shows that manipulating the UPR pathway can restore brain function and reduce aging-related deficits.

This study uses multi-omics analyses to investigate how different intermittent fasting regimens affect heart function and molecular pathways in mice.

This study identifies gene expression and cortical volume correlations across the life course and aging, revealing astrocyte-related mechanisms and phenotypic traits linked to brain development and aging.

This study uses scRNA-seq to analyze yeast ageing, finding increased transcriptional variability and identifying FIT3 as a marker of early heterogeneity.

The paper presents experiment-matched datasets of RNAs, proteins, metabolites, and lipids in budding yeast during the cell cycle, revealing coordinated control of lipid metabolism.

This study shows intermittent fasting modulates H3K9me3 epigenetic marks and transcriptomic changes in mouse cerebellum, with lasting effects after refeeding.

The paper identifies translational control of methionine and serine metabolic pathways as the mechanism underlying paralog-specific phenotypes in Rpl22 ribosomal protein mutants, linking these changes to cell division and replicative longevity.