Author
Icahn School of Medicine at Mount SinaiORCID 0009-0008-9056-1480Unclaimed ORCID profile · follow to get notified of new preprints
Mutual co-authors in cluster
7 papers
Recent·Most cited
Raphael Kübler, Daniele Mattei, Josep Oriol Narcís…·Towfique Raj
The paper identifies microglial states associated with Parkinson's disease genetic risk and Lewy body pathology using single-cell profiling and integrates data with AMP PD.
Mikaela R. Rosen, J. Oriol Narcis Majos, Daniele Mattei…·Towfique Raj
This study uses single-cell RNA sequencing and TCR profiling to analyze immune changes in Parkinson's disease across different stages and identifies sex-dependent immune alterations and TCR diversity.
Beomjin Jang, Kailash BP, Alex Tokolyi…·Towfique Raj
SingleBrain integrates snRNA-seq and genotype data to map cis-eQTLs across brain cell types, identifying novel disease-associated genes and causal variants.
Daniele Mattei, Erica Brophy, Mikaela Rosén…·Towfique Raj
The paper identifies integrated stress response (ISR) signatures and proteostasis defects in monocytes from GBA1- and LRRK2-linked Parkinson's disease, linking them to immune dysfunction.
Winston H. Dredge, Kailash BP, Aline Réal…·Towfique Raj
The paper identifies 38,731 edQTLs in 3,554 genes through a meta-analysis of A-to-I RNA editing in the human brain and links 24 GWAS loci for neurological disorders to edQTLs.
Aline Réal, Kailash BP, Winston H. Dredge…·David A. Knowles
The paper maps genetic effects on splicing in 10,725 brain samples, identifying 68,358 cis-sQTLs and 97 loci where splicing mediates neurological disease risk.
Tatsuhiko Naito, Kosei Hirata, Beomjin Jang…·Towfique Raj
The paper finds that mosaic chromosomal alterations in blood are associated with increased Alzheimer's disease risk, with variations by ancestry, mCA subtype, APOE ε4 status, and chromosomal location.