Emma E. Walsh

This study identifies how PIP3 activates an ancestral Tec kinase by displacing its PH domain from an inhibitory interaction with its kinase domain.

This study identifies ARMH3 as a central scaffold at the Golgi/TGN by defining its interactions with Arl5, PI4KB, and GBF1 using HDX-MS and AI modeling.

This study investigates how different regulatory subunits modulate p110α activity and finds no significant differences in lipid kinase activity or conformational changes across subunit variants.