BiochemistrybioRxivPreprint
Tryptophan and IFN-γ Differentially Modulate Cellular Uptake, Intracellular Trafficking, and Gene Expression of Messenger RNA-Loaded Lipid Nanoparticles in Dendritic Cells
Zitao Ma, Reena Jatyan, Nikki Crowley…·Kuo‐Ching Mei
This study shows how IFN-γ and tryptophan deprivation affect mRNA-LNP uptake, trafficking, and translation in dendritic cells, revealing distinct mechanisms of suppression.
DOI 10.1101/2025.07.10.664160