Jobin John Jacob

This study analyzes plasmid dynamics in CRKp clones to show lineage-specific resistance-virulence convergence through distinct plasmid configurations.

The paper develops and validates a genomics-informed multiplex PCR assay to specifically detect typhoidal Salmonella serovars, achieving high specificity and sensitivity.

Mykrobe k-mer panel genotypes Salmonella Typhi lineages, antimicrobial resistance (AMR) markers and plasmids from Illumina or nanopore reads, matching mapping-based lineage calls for 99.8% of genomes.

The paper analyzes S. Paratyphi A isolates to show genome degradation and gene flux drive lineage evolution, with implications for public health surveillance.

The paper analyzes SARS-CoV-2 genetic variants to identify stabilizing and destabilizing mutations and their impact on viral protein structure and function.

This study analyzes ceftriaxone-resistant Salmonella Typhi isolates from India, finding that resistance arises from plasmid acquisition, with IncX3 and IncN plasmids contributing to sporadic resistance while IncY plasmids are associated with outbreaks in Pakistan.

The paper characterizes nine novel multidrug-resistant hypervirulent Klebsiella pneumoniae isolates in India, which harbor mosaic plasmids containing both antimicrobial resistance and virulence genes.