Author

A Hoffman

Case Western Reserve UniversityORCID 0009-0009-7776-1733Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1

Signature Assays, Organisms & Methods

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Assay:cryo-EM· 1 Approach:microscopy & imaging analysis· 1 Research Focus:protein structure prediction· 1

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Changping ZhouiD· 1 shared Guadalupe Segura-CovarrubiasiD· 1 shared Nami TajimaiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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3 top collaborators · 3 mutual co-author links

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1 shared paperBiophysics

Changping ZhouORCID

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1 paper

Recent·Most cited

BiophysicsScience AdvancesPeer-reviewedJul 31, 2026

Cryo-EM Structures of Apo, Agonist- and Antagonist-Bound Heteromeric Kainate Receptors

Changping Zhou, Guadalupe Segura-Covarrubias, A Hoffman, Nami Tajima

The paper determines cryo-EM structures of GluK2/GluK5 kainate receptors in apo and ligand-bound states, revealing conformational differences and subtype-specific antagonist effects.

DOI 10.1126/sciadv.ady7558

cryo-EMmicroscopy & imaging analysis

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