Author

Guadalupe Segura-Covarrubias

Case Western Reserve UniversityORCID 0000-0002-0979-181XUnclaimed ORCID profile · follow to get notified of new preprints

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Guadalupe Segura-Covarrubias1 paper · Case Western Reserve University

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:cryo-EM· 2 Approach:microscopy & imaging analysis· 2 Research Focus:protein structure prediction· 2 Research Focus:cell type annotation· 1 Approach:experimental assay· 1

Frequent Co-Authors

Changping ZhouiD· 2 shared Nami TajimaiD· 2 shared A HoffmaniD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

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3 top collaborators · 3 mutual co-author links

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2 shared papersBiophysics

Changping ZhouORCID

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2 papers

Recent·Most cited

BiophysicsScience AdvancesPeer-reviewedJul 31, 2026

Cryo-EM Structures of Apo, Agonist- and Antagonist-Bound Heteromeric Kainate Receptors

Changping Zhou, Guadalupe Segura-Covarrubias, A Hoffman, Nami Tajima

The paper determines cryo-EM structures of GluK2/GluK5 kainate receptors in apo and ligand-bound states, revealing conformational differences and subtype-specific antagonist effects.

DOI 10.1126/sciadv.ady7558

cryo-EMmicroscopy & imaging analysis

𝕏 PostBluesky

BiophysicsNature CommunicationsPeer-reviewedDec 9, 2025

Structural Insights into Kainate Receptor Desensitization

Changping Zhou, Guadalupe Segura-Covarrubias, Nami Tajima

This paper presents cryo-EM structures of kainate receptors showing conformational changes during desensitization and identifies structural differences from other iGluRs.

7 citations

cryo-EMexperimental assay

𝕏 PostBluesky