Rintaro Tanimoto

The paper demonstrates that the fluorescent probe DAF FM DA can specifically label collagen matrices in avian embryos, enabling high-resolution imaging of collagen structures during morphogenesis.

This study shows that loss of actinodin1 and actinodin2 genes in fish causes collagen fibers to orient perpendicularly to the epidermis, leading to fin reduction and thickening, and reveals similar patterns in tetrapod limbs.