Phenotypic Resistance of Ciprofloxacin and Azithromycin Resistant Campylobacter Isolates to an Extended Panel of Antibiotics.

Lucero Romaina Cachique; Francesca Schiaffino; Maribel Paredes Olórtegui; Katia Manzanares Villanueva; Tackeshy N. Pinedo Vasquez; Alejandra Castro; Juana Najarro; Kerry K. Cooper; Evangelos Mourkas; Ben Pascoe; Pablo Peñataro Yori; Craig Thomas Parker; Margaret  N. Kosek

doi:10.64898/2026.02.06.704332

MicrobiologybioRxivFeb 10, 2026

Preprint

Phenotypic Resistance of Ciprofloxacin and Azithromycin Resistant Campylobacter Isolates to an Extended Panel of Antibiotics.

Lucero Romaina Cachique iD, Francesca Schiaffino iD, Maribel Paredes Olórtegui iD, Katia Manzanares Villanueva iD, Tackeshy N. Pinedo Vasquez iD, Alejandra Castro iD, Juana Najarro, Kerry K. Cooper iD, Evangelos Mourkas iD, Ben Pascoe iD, Pablo Peñataro Yori iD, Craig Thomas Parker iD, Margaret N. Kosek iD

Abstract

In this study we explored phenotypic resistance using traditional Kirby-Bauer methods in human and animal derived Campylobacter isolates that were concurrently resistant to both azithromycin and ciprofloxacin to an expanded panel of antimicrobials, including clindamycin, fosfomycin, ampicillin sulbactam and tigecycline. Out of 236 Campylobacter isolates, over 85% of C. jejuni and C. coli were resistant to clindamycin, over 60% were resistant to ampicillin sulbactam and over 30% to fosfomycin. Less than 2% of isolates were resistant to tigecycline and there was no observed resistance to Imipenem.

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