Bioinformatics analysis for L polymerase homology of arenaviruses

Many pathogenic viruses can transmit between human and animals as zoonotic viruses and cause dangerous diseases with obvious clinical signs globally. However, the world deals seriously with these viruses when the viruses infected either human or animals especially if the infection were confirmed that classified as zoonotic (Lal et al. 2005). There are many viruses distribution in many countries around the world including Ebolavirus, Marburgvirus, SARS and MERS coronaviruses, Hendra, Nipah and arenavirus haemorrhagic fever viruses were categorized as zoonotic RNA viruses that cause epidemic in some regions such as African countries (Fichet-Calvet & Rogers 2009) (Ehichioya et al. 2010). Consequently, structural bioinformatics of virus protein like L polymerase of arenaviruses was used for monitor the future outbreak that could be happens by new species of viruses. At this research, significant similarities with hemorrhagic fever viruses including arenaviruses were found on GenBank database. Translated blast (tBLASTn) available on https://blast.ncbi.nlm.nih.gov/Blast.cgi was used for searching translated nucleotide databases using a protein query of arenavirus L polymerase (McGinnis & Madden 2004). At this research, the new and archival metazoan transcriptome sequence data of the new TSA species that available on NCBI was used for identification with arenaviruses genes. Therefore, structure bioinformatics was utilized for better understanding and predication the evolution and natural history of the pools of uncharacterized virus on Genbank database that have led to emerging haemorrhagic fever in near future around the world.