Juan Reguera

Stepwise assembly and mechanical stability of nsP3 Helical Scaffolds in Chikungunya Virus

This study investigates the stepwise assembly and mechanical stability of nsP3 helical scaffolds in Chikungunya Virus using HS-AFM and EM, revealing domain-specific contributions to scaffold formation and function.

Hantaan virus polymerase has an in vitro Terminal Nucleotidyl Transferase activity that is conserved across the Bunyaviricetes class

This study identifies terminal nucleotidyl transferase activity in Hantaan virus L protein and shows it is conserved across Bunyaviricetes class viruses.

Smc5/6 - microtubules binding shapes pericentromeric chromatin

This study shows that Smc5/6 microtubule binding constrains chromatin dynamics and promotes pericentromeric folding in yeast, safeguarding genome stability during mitosis.

Structural basis of Ty1 integrase tethering on RNA polymerase III for targeted DNA integration

This study determines the structural basis of Ty1 integrase interaction with RNA polymerase III, revealing key residues and conformational changes that facilitate targeted DNA integration.

Structural basis and dynamics of Chikungunya alphavirus RNA capping by the nsP1 capping pores

This paper provides structural and biochemical insights into the Chikungunya virus nsP1 capping pores' RNA capping mechanism, revealing key intermediates and dynamics of the reaction pathway.