Author

Marcus Tullius Scotti

University of North Carolina at Chapel HillORCID 0000-0003-4863-8057Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:statistical model· 2 Approach:deep learning· 1 Organism:human· 1 Organism:non-human primate· 1

Frequent Co-Authors

Alexander TropshaiD· 2 shared Cleber Camilo Melo-FilhoiD· 2 shared Eugene N. MuratoviD· 2 shared Holli‐Joi MartiniD· 2 shared Alexey V. ZakharoviD· 1 shared Brandon NovyiD· 1 shared Chonny Herrera‐AcevedoiD· 1 shared Emily M. LeeiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersMicrobiology

Alexander TropshaORCID

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2 papers

Recent·Most cited

MicrobiologybioRxivPreprintJul 10, 2026

AI-Driven Discovery and BSL-4 Validation of Cross-Filovirus Ebola-Marburg Inhibitors and their Synergistic Combinations

Holli‐Joi Martin, Marcus Tullius Scotti, Sankalp Jain…·Eugene N. Muratov

This paper identifies broad-spectrum filovirus inhibitors using computational screening and validates them against multiple viral species, finding synergistic compound pairs effective against Ebola and Marburg viruses.

DOI 10.64898/2026.07.09.737586

deep learningstatistical model

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BioinformaticsbioRxivPreprintSep 26, 2025

Conserved Filovirus Proteins as Targets of Broad-Spectrum Antivirals

Marcus Tullius Scotti, Enes Kelestemur, Holli‐Joi Martin…·Eugene N. Muratov

This study identifies conserved binding sites in filovirus proteins to guide the development of broad-spectrum antivirals, finding high conservation in L and VP40 proteins and validating existing drugs like Remdesivir.

2 citations

humannon-human primate

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