Dissecting the clonality of I1 plasmids using ORF-based binarized structure network analysis of plasmids (OSNAp)
M. Suzuki, C. Norizuki, J.-i. Wachino, K. Kawamura, N. Nagano, Y. Nagano, W. Hayashi, K. Kimura, Y. Doi, Y. Arakawa
Abstract
Phylogenetic relationship of 97 I1 plasmids harboring blaCTX-M genes encoding extended-spectrum beta-lactamase (ESBL) was analyzed using the ORF-based binarized structure network analysis of plasmids (OSNAp). The majority of plasmids carrying blaCTX-M-1 or blaCTX-M-8, ESBL genes primarily associated with domestic animals, were clonal. On the other hand, plasmids carrying blaCTX-M-14 or blaCTX-M-15, identified from both humans and domestic animals, were diverse in their contents. The findings suggest that circulation of I1 plasmids among humans and animals may contribute to their diversity.
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