Iren Høyland Löhr

The paper develops a rules-based classifier to predict ciprofloxacin resistance in Klebsiella pneumoniae from genotype data and demonstrates its global distribution association with quinolone consumption.

The paper uses evolutionary accumulation modelling to infer and forecast shared evolutionary pathways to multi-drug resistance across global pathogens.

This study shows that probiotic Bifidobacteria in infants reduce antibiotic-resistant pathobionts by altering gut metabolism and resistome.

This study tracks the in vivo evolution of an antibiotic-resistant E. coli strain in an infant gut, showing a reduction in IS26-mediated resistance gene arrays without fitness or susceptibility changes.

This study characterizes the diversity and niche associations of plasmids in Klebsiella pneumoniae species complex isolates from human, animal, and marine sources, revealing distinct patterns of antimicrobial resistance and virulence gene distribution.

This paper uses genomic data from 47k Klebsiella pneumoniae genomes to predict AMR evolutionary pathways across 102 countries, showing how resistance traits vary with geography and drug policy.

The paper benchmarks 44 tools for plasmidome reconstruction from short-read assemblies in Klebsiella pneumoniae, finding PlaScope and MOB-suite as top performers.

Kaptive v3 improves antigen typing accuracy and speed for KpSC genomes by addressing assembly fragmentation issues, enabling efficient in silico serotyping.

This study analyzes KpSC populations across human, animal, and marine sources in Norway, showing distinct yet overlapping populations with limited recent transmission between niches.

This paper reclassifies SHV β-lactamase alleles in K. pneumoniae genomes based on mutations, improving genotype-phenotype understanding and updating the Kleborate tool.

The paper identifies two Klebsiella pneumoniae isolates with convergent virulence and multidrug resistance genes on a single plasmid, highlighting the risk of rapid emergence of hypervirulent multidrug-resistant strains.