NETGE-PLUS: standard and network-based gene enrichment analysis in human and model organisms

Omics techniques provide a spectrum of information that needs to be disentangled to characterize complex traits at the molecular level. The gap between genotype and phenotype must be closed by reconciling the genome information with the set of molecular pathways and biological processes describing the phenotype. In dealing with this problem, gene enrichment analysis has become the most widely adopted strategy. Here, we present NETGE-PLUS, a web-server for standard and network-based functional interpretation of gene sets of human and of model organisms, including S. scrofa, S. cerevisiae, E. coli and A. thaliana. NETGE-PLUS enables the functional enrichment of both simple and ranked lists of genes, also introducing the possibility of exploring relationships among KEGG pathways. A web interface makes data retrieval complete and user-friendly. NETGE-PLUS is publicly available at http://net-ge2.biocomp.unibo.it