Genome biologyGeneticsPeer-reviewed journal article
GBAT: a gene-based association method for robust trans-gene regulation detection
Xuanyao LiuiD, Joel MeffordiD, Andrew DahliD, Yuan HeiD, Meena SubramaniamiD, Alexis J. BattleiD, Alkes L. PriceiD, Noah ZaitleniD
Abstract
Identification of trans-eQTLs has been limited by a heavy multiple testing burden, read-mapping biases, and hidden confounders. To address these issues, we developed GBAT, a powerful gene-based method that allows robust detection of trans gene regulation. Using simulated and real data, we show that GBAT drastically increases detection of trans-gene regulation over standard trans-eQTL analyses.
- Citations
- 45
- FWCI
- 4.39
- Field percentile
- top 4%
Reproducibility ledger
Nobody has reported trying to reproduce this paper yet. Did you replicate an experiment or run the code? Your report saves the next lab a week.
Sign in to file a reproducibility report.
Related papers
- Trex-QTL: A mixture-model for identification of genetic effects with global effects on molecular phenotypes
Cynthia Wu, Andrey V. Bzikadze, … Melissa Gymrek·bioRxiv·Aug 17, 2026
- Joint eQTL mapping and Inference of Gene Regulatory Network Improves Power of Detecting both cis- and trans-eQTLs
Xin Hua Zhou, Xiaodong Cai·BioinformaticsPeer-reviewed·Sep 6, 2021
- Large-scale trans-eQTLs affect hundreds of transcripts and mediate patterns of transcriptional co-regulation
Boel Brynedal, JinMyung Choi, … Chris Cotsapas·bioRxiv·May 31, 2016
- Adjusting for genetic confounders in transcriptome-wide association studies leads to reliable detection of causal genes
Siming Zhao, Wesley L. Crouse, … Xin He·bioRxiv·Sep 27, 2022
- Trans-eQTL mapping in gene sets identifies network effects of genetic variants
Lili Wang, Nikita Babushkin, … Xuanyao Liu·Cell GenomicsPeer-reviewed·Apr 1, 2024
- BaseQTL: a Bayesian method to detect eQTLs from RNA-seq data with or without genotypes
Elena Vigorito, Wei‐Yu Lin, … Chris Wallace·bioRxiv·Jul 16, 2020