The paper introduces a novel dual-spike-in normalization method for ChIP-seq, demonstrating its ability to clarify the relationship between RNA polymerase II activity and histone modifications.

Nature Genetics · Aug 25, 2026Peer-reviewedGenomics

Trex-QTL: A mixture-model for identification of genetic effects with global effects on molecular phenotypes

Cynthia Wu, Andrey V. Bzikadze, Tian Han Xu, Eric M. Mendenhall, Hao Chen, Francesca Telese, Oksana Polesskaya, Daniel B. Munro, Abraham A. Palmer, Alon Goren, Melissa Gymrek

Trex-QTL identifies trans-eQTLs with global effects on molecular phenotypes, showing improved power and replicating known loci in rat brain data.

bioRxiv · Aug 17, 2026 · PreprintGenomics

Multiplexed measurements of protein-protein interactions and protein abundance across cellular conditions using Prod&PQ-seq

Tianyao Xu, Jingyao Wang, Yoonju Shin, Yuwei Cao, Lingzhi Zhang, Eduardo Modolo, Tamar Dishon, Jeremy Fisher, Matthew Norton, Christopher J. Fry, Yossi Farjoun, Eric M. Mendenhall, Sven Heinz, Christopher W. Benner, Alon Goren

Prod&PQ-seq detects and quantifies protein-protein interactions and protein abundance across different cellular conditions, showing changes in PRC2 interactions with EZH2 inhibition and H3 variants.

bioRxiv · Jan 14, 2026 · PreprintGenomics