Does Temperature Change Worsen Or Mitigate The Effect Of Malaria Infection On Erythrocyte Deformability?

Abstract

INTRODUCTION INTRODUCTION METHODS RESULTS AND DISCUSSION REFERENCES This paper attempts to investigate whether temperature change worsen or mitigate the effect of Plasmodium falciparum (P. falciparum) infection and maturation on the deformability of malaria-infected red blood cells (iRBCs) or erythrocytes. P. falciparum infection is the most lethal malaria parasitic infection affecting humans [1]. Upon infection, the merozoites enter the bloodstream and develop through the ring (Pf-rRBC), trophozoite (Pf-tRBC) and schizont (Pf-tRBC) stages, which is usually accompanied by significant changes in body temperature. Hence, this study aims to draw a connection between temperature change and erythrocyte deformability upon malaria infection. ...