UALCAN Mobile, an app for cancer proteogenomic data analysis.

Abstract

Cancer is a complex disease affecting various organs and is a major cause of death worldwide. During cancer initiation, disease progression, and tumor metastasis, various genomic and proteomic alterations are observed. Recent technological advances have led to the generation of large amounts of molecular data, including genomics and transcriptomics. These large-scale datasets can be utilized to analyze and identify sub-class-specific cancer biomarkers and targets. However, there is a need for the development of user-friendly tools for large-scale data analysis, disseminating the analyzed data in a visualizable format to cancer researchers with no programming skills. We developed UALCAN, a comprehensive platform that allows users to integrate disparate data to better understand the genes, proteins, and pathways perturbed in cancer and make discoveries of potential biomarkers and targets. In the current study, we describe the development of the UALCAN Mobile application (app) that will provide cancer transcriptomic data obtained from The Cancer Genome Atlas (TCGA) project to evaluate protein-coding gene expression based on various stratifications, including stage, grade, race, gender, and molecular-subtypes across over 30 types of cancers. In addition, the UALCAN mobile provides data analysis options for epigenetic changes due to DNA promoter methylation and Clinical Proteomic Tumor Analysis Consortium (CPTAC) cancer proteomic data. The app provides access to large cancer molecular datasets on the go. To find changes in the expression of causative genes and proteins and to identify biomarkers and therapeutic targets, UALCAN mobile app will be extremely valuable. The "UALCAN Mobile" app is free to use and can be downloaded from both the iOS/Apple and the Android Play Store and has been downloaded over 100 times in each of iOS and android app stores. Key PointsO_LICancer, a complex disease affecting various organs, is a major cause of death worldwide. C_LIO_LIMany molecular alterations, gene and protein expression changes lead to the initiation of cancer, disease progression, and tumor metastasis. C_LIO_LIThe available large genomic and proteomics datasets can be utilized to analyze and identify sub-class-specific cancer biomarkers and targets with innovative tools. C_LIO_LIUALCAN Mobile application (app) will provide gene expression, promoter DNA methylation, and protein expression across cancers based on various stratifications, including stage, grade, and molecular subtypes across over 30 types of cancers. C_LIO_LIUALCAN Mobile app is free and can be downloaded from both iOS/Apple and the Android Play Store. C_LI