Chad J. Creighton

Rat somatic genome editing enables ER+ breast cancer modeling

This study enables efficient somatic genome editing in rats to model ER+ breast cancer, showing that rat tumors recapitulate key features of human ER+ breast cancer not observed in mice.

UALCAN Mobile, an app for cancer proteogenomic data analysis.

UALCAN Mobile provides cancer proteogenomic data analysis through an app, enabling users to explore gene, protein, and epigenetic changes across multiple cancer types and stratifications.

Noncanonical Wnt/Ror2 Signaling Regulates Basal Cell Fidelity and Branching Morphogenesis in the Mammary Gland

This study shows that noncanonical Wnt signaling via Ror2 maintains basal cell identity in mammary glands, preventing fate transitions to luminal cells and ensuring proper branching morphogenesis.

MAGE-A4-Responsive Plasma Cells Promote Non-Small Cell Lung Cancer

The paper shows MAGE-A4 promotes NSCLC by recruiting IgA+ plasma cells, reducing tumor burden and enhancing T cell activity.

Renal carcinoma is associated with increased risk of coronavirus infections

The paper analyzes gene and protein expression of coronavirus receptors in renal carcinoma and normal tissues, finding increased expression of ACE2, DPP4, ANPEP, and ENPEP in renal tumors and associations with immune infiltration and T cell exhaustion.

Tead1 reciprocally regulates adult β-cell proliferation and function to maintain glucose homeostasis

This study shows TEAD1 regulates adult β-cell proliferation and function, maintaining glucose homeostasis by balancing quiescence and mature identity in mice and humans.

Comprehensive Molecular Characterization of Mitochondrial Genomes in Human Cancers

This study characterizes mitochondrial genomes in 2,700 cancer patients across 37 types using whole-genome sequencing and RNA-seq, revealing mutational patterns, truncating mutations, and nuclear transfer of mitochondrial DNA.

Whole genome and RNA sequencing of 1,220 cancers reveals hundreds of genes deregulated by rearrangement of cis-regulatory elements

The paper identifies hundreds of genes deregulated by SVs in cancer, showing increased expression linked to SV breakpoints and enhancer elements.

Genomic basis for RNA alterations revealed by whole-genome analyses of 27 cancer types

The paper analyzes RNA alterations across 27 cancer types using whole-genome sequencing data, identifying gene expression associations with DNA variants and structural fusions.

The whole-genome panorama of cancer drivers

This paper identifies driver mutations across 2,500 tumors from 37 cancer types, revealing a whole-genome panorama of genomic events that underlie tumor development.