Prospective control of movement in the basal ganglia

Abstract

Neural systems control purposeful movements both within an animals body (e.g., pumping blood) and in the environment (e.g., reaching). This is vital for all animals. The movement control functions of globus pallidus (GP), subthalamic nucleus (STN) and zona incerta (ZI) were analyzed in monkeys reaching for seen targets. Temporal profiles of their hand movements and the synchronized pattern of neuropower (rate of flow of electrochemical energy) through the basal ganglia were analyzed in terms of general tau theory of movement control (Lee et al., 2009), using the variable rho (=1/tau). The results suggest: (i) the neuroinformation for controlling movement is the relative-rate-of-change, rho, of neuropower in the nervous system; (ii) GP is involved in creating prescriptive rhos of neuropower to guide movements; (iii) STN is involved in registering perceptual rhos of neuropower to monitor the movement; (iv) ZI is involved in combining the prescriptive and perceptual rhos of neuropower to generate performatory rhos of neuropower to activate the muscles to produce the movement. Possible implications for Parkinsons disease are discussed.