Arin Pamukcu

The paper investigates how dopamine modulates tonic GABAergic signaling in the substantia nigra via astrocytic and dopaminergic neuron interactions.

The paper investigates the neural mechanisms of antipsychotic drugs by comparing their effects on D1- and D2-receptor-expressing spiny-projection neurons in mice, finding that modulating D1-SPNs correlates with therapeutic efficacy.

This study identifies distinct GPe neuron subtypes using mouse lines and shows their unique roles in motor behavior and anxiety-like behavior through optogenetics and machine learning.

This study identifies that direct-pathway striatal projection neurons (dSPNs) target Npas1+ neurons in the external globus pallidus (GPe) and show that this projection suppresses movement, contributing to Parkinson's disease hypokinesia.

This study identifies distinct roles of PV+ and Npas1+ neurons in the GPe for locomotion and shows differences in their synaptic inputs from the STN in Parkinson's disease.

The paper identifies Npas1+-Nkx2.1+ neurons as a distinct subclass of GPe neurons and describes their role in the cortico-pallido-cortical loop.