Chronic Polystyrene Nanoplastics Exposure Reprograms Gene Expression, Alternative Splicing, and Disrupts Host Microbiome Metabolic Networks to Promote Atherosclerosis in LDLr- Knockout Mice

Although micro- and nanoplastics have been detected in human atherosclerotic plaques, their mechanistic contribution to disease pathogenesis remains poorly defined. Most experimental studies have used microplastics (particles > 1 m) in non-atherosclerotic animal models or the ApoE-/- mouse, relying on short-term exposure or single-pathway analyses, whereas the chronic cardiovascular effects of nanoplastics ( View larger version (41K): org.highwire.dtl.DTLVardef@196ad0eorg.highwire.dtl.DTLVardef@13b95d3org.highwire.dtl.DTLVardef@e963c4org.highwire.dtl.DTLVardef@94f60c_HPS_FORMAT_FIGEXP M_FIG Graphical Abstract C_FIG