Tariq Khan

History of opioid use disorder correlates with altered neuroimmune signatures in the human dorsal root ganglia

The paper examines molecular and physiological changes in dorsal root ganglia from individuals with and without opioid use disorder, identifying altered neuroimmune signatures and sensitized sensory neurons.

Chronic lower limb pain is not associated with a loss of inhibitory neurons in the human lumbar spinal dorsal horn

This study examines the anatomical changes in the human lumbar spinal dorsal horn in relation to chronic lower limb pain and finds no association with neuronal density or inhibitory neuron loss.

Polystyrene microplastic uptake drives Inflammatory, Epitranscriptomic, and Metabolic Reprogramming in Human Aortic Endothelial cells

This study shows that polystyrene microplastics induce inflammatory, epitranscriptomic, and metabolic changes in human aortic endothelial cells, potentially contributing to cardiovascular disease.

Nav1.8 mediates peripheral-to-central nociceptive transmission independently of central presynaptic mechanisms in human DRG-spinal cord circuits

This study shows that Nav1.8 blockers reduce spinal CGRP release only when applied to peripheral sites, indicating their mechanism acts at the peripheral level rather than the central nervous system.

Progressive neurodegeneration in human dorsal root ganglion from diabetes to painful neuropathy

The paper investigates neurodegeneration in dorsal root ganglia across diabetes and diabetic painful neuropathy stages, identifying early molecular changes and highlighting the need for early intervention.

A molecular map of the human spinal dorsal and ventral horn defines arrangement of neuronal types and glial sex differences

The paper maps molecular features of human spinal cord dorsal and ventral horns, identifying neuronal types and sex-specific glial differences using single-nucleus sequencing and spatial transcriptomics.

Decreased KCC2 expression in the human spinal dorsal horn associated with chronic pain and long-term opioid use

Spatial transcriptomic profiling of human paravertebral sympathetic chain ganglia reveals diabetes-induced neuroplasticity

This paper uses spatial transcriptomics to analyze human sympathetic chain ganglia in diabetes, identifying neuronal and non-neuronal changes linked to autonomic dysfunction.