bioRxivCell Biology
Anatomical Structures, Cell Types, and Biomarkers Tables Plus 3D Reference Organs in Support of a Human Reference Atlas
K. Borner, S. A. Teichmann, E. M. Quardokus, J. Gee, K. Browne, D. Osumi-Sutherland, B. W. Herr, A. Bueckle, H. Paul, M. A. Haniffa, L. Jardine, A. Bernard, S.-L. Ding, J. A. Miller, S. Lin, M. Halushka, A. Boppana, T. A. Longacre, J. Hickey, Y. Lin, M. T. Valerius, Y. He, G. Pryhuber, X. Sun, M. Jorgensen, , G. Weber
Abstract
1.This paper reviews efforts across 16 international consortia to construct human anatomical structures, cell types, and biomarkers (ASCT+B) tables and three-dimensional reference organs in support of a Human Reference Atlas. We detail the ontological descriptions and spatial three-dimensional anatomical representations together with user interfaces that support the registration and exploration of human tissue data. Four use cases are presented to demonstrate the utility of ASCT+B tables for advancing biomedical research and improving health.
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