S. A. Teichmann

Integrated histopathology, spatial and single cell transcriptomics resolve cellular drivers of early and late alveolar damage in COVID-19

This study integrates single-cell and spatial transcriptomics with histopathology to identify cellular and molecular changes in lung alveolar damage during COVID-19 progression.

Generation of transplantable and biologically responsive colonic tissue from human induced pluripotent stem cells using a rapid co-differentiation platform.

This paper develops a co-differentiation platform using human iPSCs to generate transplantable colonic tissue that mimics native mucosa and responds to biological signals.

Polybacterial intracellular coinfection of epithelial stem cells in periodontitis

This study identifies polybacterial intracellular co-infection in human periodontal epithelial cells, revealing its proinflammatory effects and potential role in chronic diseases.

Multi-scale spatial mapping of cell populations across anatomical sites in healthy human skin and basal cell carcinoma

The paper creates a multi-scale spatial atlas of healthy human skin and basal cell carcinoma using various omics and imaging techniques, revealing cell population localization and origins.

CLICK-chemoproteomics and molecular dynamics simulation reveals pregnenolone targets and their binding conformations in Th2 cells

The paper identifies pregnenolone targets and their binding conformations in Th2 cells using chemoproteomics and molecular dynamics simulations.

The emergence of goblet inflammatory or ITGB6hi nasal progenitor cells determines age-associated SARS-CoV-2 pathogenesis

The study identifies age-related differences in nasal epithelial cell responses to SARS-CoV-2 infection, showing distinct progenitor cell dynamics in children and elderly.

Transcriptional signals of dedifferentiation in human cancer

This study examines dedifferentiation in cancer using single-cell atlases, finding that adult cancers do not revert to an embryonic state but retain foetal signals, while childhood cancers show universal foetal state features.

Mapping the developing human immune system across organs

This study maps the developing human immune system across organs using single-cell RNA sequencing, antigen-receptor sequencing, and spatial transcriptomics, revealing cross-gestation and cross-organ variability and identifying prenatal B1 cells and unconventional T cell origins.

Obesity associated with attenuated tissue immune cell responses in COVID-19

The paper finds that obesity is associated with reduced immune and inflammatory responses in COVID-19 patients, including lower expression of IFN and IFNγ response genes in lung and blood cells.

SARS-CoV-2 Omicron spike mediated immune escape, infectivity and cell-cell fusion

This study investigates the immune escape, infectivity, and cell-cell fusion properties of SARS-CoV-2 Omicron BA.1 compared to Delta, showing higher ACE2 affinity and antibody evasion but similar antiviral drug efficacy.

A spatial multi-omics atlas of the human lung reveals a novel immune cell survival niche

The paper creates a spatial multi-omics lung atlas identifying novel cell types and a survival niche for IgA-secreting plasma cells in submucosal glands.

Anatomical Structures, Cell Types, and Biomarkers Tables Plus 3D Reference Organs in Support of a Human Reference Atlas

The paper reviews efforts to create human anatomical structures, cell types, and biomarkers tables and 3D reference organs to support a Human Reference Atlas, with use cases showing their utility in biomedical research.

Cross-tissue immune cell analysis reveals tissue-specific adaptations and clonal architecture across the human body

The paper analyzes immune cell diversity across 15 human tissues using single-cell RNA sequencing and VDJ sequencing, revealing tissue-specific features and clonal architecture of T and B cells.

Cells of the human intestinal tract mapped across space and time

The paper maps human intestinal cell lineages across development and disease, identifying new cell types and functions related to inflammation and immunity.

Integrated Single Cell Atlas of Endothelial Cells of the Human Lung

The paper reanalyzes six scRNA-seq datasets to create a comprehensive reference atlas of human lung endothelial cells, identifying new subpopulations and confirming their conservation in mice.

Rora regulates activated T helper cells during inflammation

This study investigates Rora's role in CD4+ T cells during inflammation, finding it regulates lung inflammation and is controlled by IL-33 and CCL7.

Tumors induce de novo steroid biosynthesis in T cells to evade immunity

This study shows tumors induce steroid synthesis in T cells to evade immunity, and blocking this pathway restores anti-tumor immunity in mouse models.

Antibody repertoire and gene expression dynamics of diverse human B cell states during affinity maturation.

The paper analyzes B cell states and antibody repertoires during affinity maturation to understand gene expression and selection dynamics.

Single cell profiling of immature human postnatal thymocytes resolves the complexity of intra-thymic lineage differentiation and thymus seeding precursors.

The paper uses single-cell RNA sequencing to analyze immature human thymocytes and identifies thymus seeding precursors and T-lineage developmental pathways.

Single-cell transcriptomics of allo-reactive CD4+ T cells over time reveals divergent fates during gut GVHD

This study uses single-cell RNA sequencing to track the differentiation of allo-reactive CD4+ T cells during gut GVHD, revealing divergent fates into quiescent and effector states.

Single-cell sequencing of developing human gut reveals transcriptional links to childhood Crohns disease

The paper maps the developing human gut at 6-10 weeks post-conception using single-cell sequencing and links fetal transcriptional patterns to childhood Crohn's disease.

A cell atlas of human thymic development defines T cell repertoire formation

This study creates a cell atlas of the human thymus using scRNA-seq, revealing new cell populations and insights into T-cell development and TCR recombination.

Distinct microbial and immune niches of the human colon

The paper examines microbial and immune cell interactions in the human colon, identifying distinct immune niches and T cell profiles along the colon.

Resolving the fibrotic niche of human liver cirrhosis using single-cell transcriptomics

This study uses single-cell transcriptomics to identify novel fibrotic cell types and interactions in human liver cirrhosis, revealing potential therapeutic targets.

Transcriptome Dynamics Reveals Progressive Transition from Effector to Memory in CD4+ T cells.

This study uses single-cell RNA-seq and ATAC-seq to show a progressive transition from effector to memory CD4+ T cells during Plasmodium infection, with linear pathways and memory-associated gene expression.

A cellular census of healthy lung and asthmatic airway wall identifies novel cell states in health and disease

The paper uses single-cell transcriptomics to identify novel cell states in healthy and asthmatic lung tissues, revealing changes in cell communication and immune responses.

Single-cell RNA sequencing reveals a dynamic stromal niche within the evolving tumour microenvironment

This study uses single-cell RNA sequencing to analyze stromal cell changes in murine melanoma, identifying distinct CAF populations and their roles in immune suppression across tumor development.

Unbiased classification of mosquito blood cells by single-cell genomics and high-content imaging

The paper uses single-cell genomics and imaging to classify mosquito blood cells, revealing transcriptional signatures and challenges to current morphology-based classification.

The IRE1a-XBP1 pathway promotes T helper cell differentiation by resolving secretory stress and accelerating proliferation

This study identifies XBP1 target genes and shows the IRE1a-XBP1 pathway resolves secretory stress and promotes Th2 cell proliferation and cytokine regulation.

Single cell transcriptomics of regulatory T cells reveals trajectories of tissue adaptation

The paper uses single-cell RNA-seq to study Treg and Tmem cells in mouse tissues, revealing a lymphoid-to-tissue adaptation trajectory and conserved molecular signals across species.