Author

L. Jardine

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Bioengineering· 1 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 7 Research Focus:cell type annotation· 6 Research Focus:differential expression· 6 Assay:scRNA-seq· 4 Approach:statistical model· 4 Approach:deep learning· 3 Assay:bulk RNA-seq· 2 Research Focus:cell-cell communication· 2

Frequent Co-Authors

M. Haniffa· 5 shared K. Polanski· 3 shared S. A. Teichmann· 3 shared S. Behjati· 3 shared E. Stephenson· 2 shared G. Reynolds· 2 shared I. Goh· 2 shared J. Engelbert· 2 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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5 shared papersImmunology

M. Haniffa

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Single cell transcriptomics reveals chondrocyte differentiation dynamics in vivo and in vitro

J. E. G. Lawrence, S. Woods, K. Roberts, D. N. Sumanaweera, P. Balogh, A. V. Predeus, P. He, T. Li, K. Polanski, E. Prigmore, E. Tuck, L. Mamanova, D. Zhou, S. Webb, L. Jardine, , S. Teichmann

This study uses single-cell transcriptomics to compare in vitro and in vivo chondrocyte differentiation, identifies off-target differentiation, and improves in vitro protocols by inhibiting FOXO1.

bioRxiv · Dec 20, 2023Bioengineering

Oncogenic RAS-Pathway Activation Drives Oncofetal Reprogramming and Creates Therapeutic Vulnerabilities in Juvenile Myelomonocytic Leukemia

M. Hartmann, M. Schoenung, J. Rajak, V. Maurer, L. Hai, K. Bauer, M. Hakobyan, S. Staeble, J. Langstein, L. Jardine, R. Roelz, S. Bohler, E. Khabirova, A.-H. Maag, D. Vonficht, , D. B. Lipka

This study identifies oncofetal reprogramming in juvenile myelomonocytic leukemia, linking RAS-pathway activation to fetal gene expression and revealing CD52 as a therapeutic target.

bioRxiv · Oct 27, 2023Cancer Biology

Mapping the developing human immune system across organs

C. Suo, E. Dann, I. Goh, L. Jardine, V. Kleshchevnikov, J.-E. Park, R. A. Botting, E. Stephenson, J. Engelbert, Z. K. Tuong, K. Polanski, N. Yayon, C. Xu, O. Suchanek, R. Elmentaite, , S. A. Teichmann

This study maps the developing human immune system across organs using single-cell RNA sequencing, antigen-receptor sequencing, and spatial transcriptomics, revealing cross-gestation and cross-organ variability and identifying prenatal B1 cells and unconventional T cell origins.

bioRxiv · Jan 17, 2022Immunology

Anatomical Structures, Cell Types, and Biomarkers Tables Plus 3D Reference Organs in Support of a Human Reference Atlas

K. Borner, S. A. Teichmann, E. M. Quardokus, J. Gee, K. Browne, D. Osumi-Sutherland, B. W. Herr, A. Bueckle, H. Paul, M. A. Haniffa, L. Jardine, A. Bernard, S.-L. Ding, J. A. Miller, S. Lin, , G. Weber

The paper reviews efforts to create human anatomical structures, cell types, and biomarkers tables and 3D reference organs to support a Human Reference Atlas, with use cases showing their utility in biomedical research.

bioRxiv · May 31, 2021Cell Biology

Poised cell circuits in human skin are activated in disease

G. Reynolds, P. Vegh, J. Fletcher, E. Poyner, E. Stephenson, I. Goh, R. Botting, N. Huang, B. Olabi, A. Dubois, D. Dixon, K. Green, D. Maunder, J. Engelbert, M. Efremova, , F. Watt

The paper creates a single-cell atlas of human skin, showing how cell circuits change in inflammatory diseases like atopic dermatitis and psoriasis.

bioRxiv · Nov 5, 2020 · PreprintImmunology

Donor monocyte-derived macrophages promote human acute graft versus host disease

L. Jardine, U. Cytlak, M. Gunawan, G. Reynolds, K. Green, X.-N. Wang, S. Pagan, M. Pradnya, C. A. Lamb, A. K. Long, E. Hurst, S. Nair, G. Jackson, A. Publicover, V. Bigley, , M. Collin

The paper identifies donor monocyte-derived macrophages as key players in human acute graft versus host disease, showing their enhanced activation of T cells and secretion of inflammatory cytokines.

bioRxiv · Sep 30, 2019Immunology

Single cell transcriptomics of regulatory T cells reveals trajectories of tissue adaptation

R. J. Miragaia, T. Gomes, A. Chomka, L. Jardine, A. Riedel, A. N. Hegazy, I. Lindeman, G. Emerton, T. Krausgruber, J. Shields, M. Haniffa, F. Powrie, S. A. Teichmann

The paper uses single-cell RNA-seq to study Treg and Tmem cells in mouse tissues, revealing a lymphoid-to-tissue adaptation trajectory and conserved molecular signals across species.

bioRxiv · Nov 22, 2017Immunology