The clinically relevant MTARC1 p.Ala165Thr variant impacts neither the fold nor active site architecture of the human mARC1 protein

Recent genome-wide association studies (GWAS) have shown a common variant of the human mARC1 protein to be associated with liver disease. Herein, we present the crystal structure of this mARC1 p.Ala165Thr at near-atomic resolution. No relevant differences between the structure of wild type mARC1 and the variant protein are detected.