Xiao Yan Han

This paper develops artificial and semi-artificial 3D membrane systems to study protein, lipid, and glycocalyx distribution at cell-cell interfaces, revealing differential partitioning and activation dynamics.

The paper decodes correlated dynamics at the pMHC interface to understand TCR recognition and immunogenicity using computational methods.

This paper designs soluble, miniaturized MHC proteins that enable stable expression in E. coli and retain peptide and TCR binding specificity.

The paper investigates MALT1 activation dynamics using a combination of AlphaFold, MD simulations, and NMR analyses, revealing how ionic strength influences its conformational states.

This study develops DARPin T cell engagers that specifically target HLA/peptide complexes on tumor cells, showing high affinity and specificity through in vitro selection and structural analysis.

This study characterizes the conformational dynamics of G3BP1 under different pH conditions and shows how its structural changes enable phase separation.

The paper investigates the dynamic behavior of MALT1 using NMR and AlphaFold to reveal interdomain motions involved in allosteric regulation.