Human Brain MappingGeneticsPeer-reviewed journal article
Genome-wide association analysis links multiple psychiatric liability genes to oscillatory brain activity
Dirk J. A. SmitiD, Margaret J. WrightiD, Jacquelyn Leigh MeyersiD, Nicholas G. MartiniD, Yvonne Y. W. Ho, Stephen M. MaloneiD, Jian ZhangiD, Scott J. BurwelliD, David Balin ChorlianiD, Eco J. C. de GeusiD, Damiaan A J P DenysiD, Narelle K. HanselliD, Jouke‐Jan HottengaiD, Matt K. McGueiD, Catharina E. M. van Beijsterveldt, Neda JahanshadiD, Paul M. ThompsoniD, Christopher D. WhelaniD, Sarah Elizabeth MedlandiD, Bernice Porjesz AiD, William G. lacono, Dorret Irene BoomsmaiD
Abstract
Oscillations in neuronal activity are widely thought to play a crucial role in information processing and cortical communication 1-8. Brain oscillations have been widely investigated as biomarkers of psychiatric disorders and variation in normal human behavior 9, 10, including intelligence 11, 12, schizophrenia 13, 14, attentional deficits 15, 16, and substance use 17, 18. Beyond the biomarker, oscillatory activity may indeed cause variation in behavior, as it has been shown that disrupting oscillatory activity by blocking GABAergic fast-spiking interneurons in the frontal cortex of mice impairs behavioral flexibility8, consistent with ...
- organism: mouse
- assay: electronic health records
- research focus: GWAS / association mapping
- approach: statistical model
- Citations
- 65
- FWCI
- 5.83
- Field percentile
- top 3%
Reproducibility ledger
Nobody has reported trying to reproduce this paper yet. Did you replicate an experiment or run the code? Your report saves the next lab a week.
Sign in to file a reproducibility report.
Related papers
- Modulating pathological oscillations by rhythmic non-invasive brain stimulation – a therapeutic concept?
Lutz A Krawinkel, Andreas K Engel, Friedhelm C Hummel·Frontiers in Systems NeurosciencePeer-reviewed·Mar 17, 2015
- The Effect of Alterations of Schizophrenia-Associated Genes on Gamma Band Oscillations
Christoph Metzner, Tuomo Mäki‐Marttunen, … Volker Steuber·SchizophreniaPeer-reviewed·Apr 28, 2022
- The genomic underpinnings of oscillatory biomarkers supporting successful memory encoding in humans
Stefano Berto, Miles R. Fontenot, … Geneviève Konopka·bioRxiv·Nov 25, 2019
- Neuromodulation of risk preferences encoded in human orbitofrontal cortex activity
Alexandra M. Fink, Lu Jin, … Ignacio Sáez·bioRxiv·May 6, 2025
- Dissociable oscillatory networks support gain and loss processing in human orbitofrontal cortex
Ignacio Sáez, Jack J. Lin, … Ming Hsu·bioRxiv·Feb 25, 2021
- Rhythmicity Revisited: Evidence from Robust Behavioral Oscillations
Mengting Xu, Esperanza R. Badaya, … Tom Verguts·bioRxiv·Dec 26, 2025