Matt K. McGue

This study identifies 1,257 genetic variants associated with human personality traits using large-scale GWAS and finds widespread genetic correlations with behaviors and life outcomes.

The paper updates a polygenic index repository with more phenotypes, datasets, and improved causal inference methods, enhancing predictive performance and interpretability.

This study performs a multi-ancestral GWAS of DSM-defined nicotine dependence, finding genetic correlations with other substance use disorders and health traits, and identifying a strong general addiction liability factor.

Family-based GWAS meta-analysis of 34 phenotypes shows standard GWAS effects carry sizeable confounding uncorrelated with direct genetic effects, while assortative mating likely inflates SNP heritability and genetic correlations.

This study identifies genetic variants associated with antisocial behavior through a genome-wide association meta-analysis, finding significant links to FOXP2 and correlations with multiple health and behavioral traits.

This study shows that polygenic scores for drinking and smoking predict alcohol and nicotine use problems from adolescence to young adulthood, with smoking PGS also capturing broader genetic liability for substance use.

The paper constructs polygenic indexes for 47 phenotypes across 11 datasets and provides a tool to correct errors-in-variables bias when using PGIs as proxies for the additive SNP factor.

This paper examines if a polygenic risk score for smoking measures genetic risk for behavioral disinhibition by analyzing its associations with externalizing psychopathology, internalizing psychopathology, and personality traits in adolescence.

The paper analyzes rare coding variants in smoking and drinking behavior using exome chip data, finding that they contribute to phenotypic variation but require larger samples for individual variant associations.

This paper evaluates LD Score regression's ability to estimate confounding and genetic correlations in GWAS, showing it can produce unbiased or conservative estimates under various conditions.