Damiaan A J P Denys

Rescuing behavioral flexibility in a mouse model for OCD by enhancing reward-cue salience

This study investigates behavioral flexibility in OCD using SAPAP3 knockout mice, finding that enhancing reward-cue salience improves reversal learning by restoring sign-tracking behavior.

Associations of schizophrenia with arrhythmic disorders and electrocardiogram traits: an in-depth genetic exploration of population samples

This study investigates genetic links between schizophrenia and arrhythmic disorders, finding specific genetic correlations and causal effects on Brugada syndrome and heart rate.

Genetic evidence for the link of misophonia with psychiatric disorders and personality

This study identifies genetic correlations between misophonia and psychiatric disorders, showing strong links with anxiety, PTSD, and specific personality traits.

Unraveling the therapeutic mechanism of deep-brain stimulation

This study investigates how deep-brain stimulation (DBS) affects neuronal activity and behavior in a mouse model of compulsive grooming, finding dose-dependent effects and specific involvement of the medial orbitofrontal cortex.

Conscious perception and the role of the basal ganglia: preliminary findings from a deep brain stimulation study

This study investigates whether deep brain stimulation of the basal ganglia improves conscious perception in OCD patients, finding behavioral improvements but no clear neural effects.

Metacognition and the effect of incentive motivation in two compulsive disorders: gambling disorder and obsessive-compulsive disorder

This study investigates metacognition and incentive motivation in gambling disorder and obsessive-compulsive disorder using fMRI, finding increased confidence in GD during gain contexts but no group differences in VMPFC activity.

How motivational signals disrupt metacognitive signals in the human VMPFC.

This study investigates how motivational signals affect metacognitive signals in the VMPFC during decision-making, finding that confidence signals are disrupted in trials with negative monetary prospects.

Exploring the relationship between schizophrenia and cardiovascular disease: A genetic correlation and multivariable Mendelian randomization study

This study investigates genetic correlations and bidirectional effects between schizophrenia and cardiovascular disease, finding schizophrenia increases heart failure risk and early repolarization risk.

Genetic correlates of socio-economic status influence the pattern of shared heritability across mental health traits

The paper investigates how genetic correlates of socio-economic status affect shared heritability across mental health traits using genome-wide association summary statistics.

Genome-wide Association Study of Pediatric Obsessive-Compulsive Traits: Shared Genetic Risk between Traits and Disorder

This study identifies a genome-wide significant variant for OC traits and shows shared genetic risk between OC traits and OCD.

Genomic relationships across psychiatric disorders including substance use disorders

The paper extends a genetic correlation analysis of psychiatric disorders by including substance use disorders, revealing changes in the latent genetic factor structure.

Deep brain stimulation modulates directional frontolimbic connectivity in obsessive-compulsive disorder

Deep brain stimulation improves mood and anxiety in obsessive-compulsive disorder by altering connectivity between the amygdala, insula and prefrontal cortex.

The effect of acute stress on the balance between goal-directed and habit networks in obsessive-compulsive disorder.

This study examines how acute stress affects neural network balance in OCD patients, finding blunted connectivity changes in the caudate nucleus linked to compulsivity.

Genetic meta-analysis of obsessive-compulsive disorder and self-report compulsive symptoms.

This paper investigates genetic correlations between compulsive symptoms and OCD using GWAS and finds novel genes and increased enrichment for brain-related genes when combining symptom data with case-control studies.

Phenome-wide investigation of health outcomes associated with genetic predisposition to loneliness

This study identifies 12 genetic loci associated with loneliness and finds genetic correlations with 34 health outcomes, including cardiovascular and psychiatric disorders.

Subcortical brain volume, regional cortical thickness and cortical surface area across attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and obsessive-compulsive disorder (OCD): findings from the ENIGMA-ADHD, -ASD, and -OCD working groups

This study compares structural brain differences across ADHD, ASD, and OCD using MRI data from multiple cohorts, finding disorder-specific alterations in brain volume and cortical thickness.

Genome-wide association analysis links multiple psychiatric liability genes to oscillatory brain activity