Geneviève Konopka

Isoflurane anesthesia CNS recovery state: ultra-slow oscillations and cellular-stress-responsive gene expression

This study compares the neurophysiological and molecular recovery from isoflurane anesthesia with sleep and sleep deprivation in mice, finding distinct gene expression patterns and EEG features.

Molecular and cell type-specific determinants of inferior colliculus development and auditory function

This study identifies gene regulatory programs and cell type-specific molecular mechanisms underlying inferior colliculus development and auditory function.

The genetic signature of memory encoding along the human hippocampal axis

The paper links hippocampal oscillatory activity during memory encoding to distinct molecular programs in anterior and posterior hippocampus using single-nucleus RNA sequencing and spatial transcriptomics.

Evolution of songbird vocal imitation involved multiple cellular innovations

The paper identifies novel cellular innovations in songbird pallium associated with vocal imitation, including specialized glutamatergic and GABAergic neurons and increased astrocyte proportions.

Resilience to Endoplasmic Reticulum Stress Mitigates Calcium-Dependent Membrane Hyperexcitability Underlying Late Disease Onset in SCA6

This study identifies ER stress and HSP90-dependent UPR as mechanisms underlying delayed onset of SCA6 motor dysfunction and Purkinje cell spiking abnormalities.

Decoding DNA sequence-driven evolution of the human brain epigenome at cellular resolution

The paper identifies evolutionary patterns in the human brain epigenome using single-cell ATAC-seq data, revealing lineage-specific regulatory changes and their association with brain disease variants.

Stimulation modulates cell assemblies linked with gene networks in the human temporal cortex ex vivo

The paper shows that stimulation increases firing rates in pyramidal cells and strengthens cell assemblies in the human temporal cortex, linked to gene networks involving excitatory neurons and non-neurons.

Evolution of the cellular landscape in mammalian striatum

The paper compares snRNA-seq data across species to identify cellular differences in the striatum, finding novel interneuron types in bats and differences in neuron-to-glia ratios between primates and non-primates.

Assigning Targetable Pathways to Transdiagnostic Subgroups Across Neurodevelopmental Disorders

The paper identifies molecular pathways associated with neurodevelopmental disorder subgroups using neuroimaging data from mice and humans.

Cell type-specific roles of FOXP1 in the excitatory neuronal lineage during early neocortical murine development

This study investigates the cell type-specific roles of FOXP1 in mouse neocortical development, revealing its impact on neurogenesis, gene expression, and cortical layering, with implications for ASD and FOXP1 syndrome.

Sleep need driven oscillation of glutamatergic synaptic phenotype

The paper shows sleep loss alters glutamatergic synaptic properties in the neocortex, which are reversed by sleep, and links these changes to sleep-related genes and MEF2c/HDAC4 regulation.

FOXP1 regulates the development of excitatory synaptic inputs onto striatal neurons and induces phenotypic reversal with reinstatement

This study shows FOXP1 regulates glutamatergic input development in striatal neurons, with potential therapeutic implications for FOXP1 syndrome.

Compensation between FOXP transcription factors maintains proper striatal function

The paper shows that Foxp1 and Foxp2 compensate for each other in D1-SPNs, and their loss causes motor and social deficits, which can be reversed by re-expressing Foxp1.

FOXP1 orchestrates neurogenesis in human cortical basal radial glial cells

This study shows FOXP1 is essential for human basal radial glial cell proliferation and differentiation, leading to increased excitatory neuron production during cortical development.

A single-cell trajectory atlas of striatal development

This study integrates single-cell RNA-sequencing data from mouse striatal development to analyze trajectory patterns and transcription factor networks, finding extended postnatal development and regulatory effects of FOXP1 on oligodendrocytes.

An extra-circadian function for human CLOCK in the neocortex

This study shows that human CLOCK has extra-circadian functions in the neocortex, enhancing cognitive flexibility and neural connectivity through altered gene expression in excitatory neurons.

Ambient RNA analysis reveals misinterpreted and masked cell types in brain single-nuclei datasets

The paper analyzes ambient RNA contamination in brain single-nuclei RNA-seq, showing it misclassifies cell types and reveals previously undetected oligodendrocyte progenitor cells after correction.

Association between resting-state functional brain connectivity and gene expression is altered in autism spectrum disorder

This study identifies genes linked to brain activity that show disrupted associations in autism spectrum disorder, highlighting excitation-inhibition imbalance and regional effects.

Expression of FoxP2 in the Basal Ganglia Regulates Vocal Motor Sequences in the Adult Songbird

This study shows FoxP2 in the basal ganglia is essential for fluent birdsong initiation, termination, and syllable sequencing, with disruptions affecting dopamine receptor balance and vocal-motor sequencing.

Zbtb16 regulates social cognitive behaviors and neocortical development.

This study shows that Zbtb16 deletion in mice causes ASD and SCZ-like behaviors and neocortical developmental defects, with associated transcriptomic changes.

Autism-linked gene FoxP1 selectively regulates the cultural transmission of learned vocalizations

This study shows that FoxP1 selectively impairs social learning of vocalizations but not imitation in zebra finches, highlighting a specific vulnerability in cultural transmission.

FOXP1 negatively regulates intrinsic excitability in D2 striatal projection neurons by promoting inwardly rectifying and leak potassium currents

The paper shows that FOXP1 reduces intrinsic excitability in D2 striatal projection neurons by increasing potassium currents through transcriptional activation of KIR and KLeak channels.

An essential role for MEF2C in the cortical response to loss of sleep

This study identifies MEF2C as essential for the biological responses to sleep loss, including gene expression changes and synaptic strength recovery.

Cell-type and cytosine context-specific evolution of DNA methylation in the human brain

The paper investigates DNA methylation evolution in human brain cells, showing reduced CG methylation and increased CH methylation, linked to schizophrenia risk.

Impairment of methylglyoxal detoxification systems causes mitochondrial dysfunction and schizophrenia-like behavioral deficits

This study shows that impaired methylglyoxal detoxification in mice leads to mitochondrial dysfunction and schizophrenia-like behaviors.

Single-cell analysis of Foxp1-driven mechanisms essential for striatal development

This study uses single-cell RNA-sequencing to investigate Foxp1's role in striatal development, identifying cell-type-specific transcriptional mechanisms and functional deficits linked to FOXP1 mutations.

The genomic underpinnings of oscillatory biomarkers supporting successful memory encoding in humans

This paper links brain oscillations to gene expression in human patients, identifying gene modules associated with memory encoding and neuropsychiatric disorders.

MEF2C hypofunction in neuronal and neuroimmune populations cooperate to produce MEF2C haploinsufficiency syndrome-like behaviors in mice

This study shows that MEF2C hypofunction in neuronal and neuroimmune populations causes MCHS-like behaviors in mice, highlighting its role in brain development and function.

Cortical Foxp2 supports behavioral flexibility and developmental dopamine D1 receptor expression

This study shows that cortical Foxp2 is essential for behavioral flexibility and dopamine D1 receptor expression, with effects on cell type composition and gene expression in the neonatal cortex.

Cell-type specific epigenetic links to schizophrenia risk in brain

The paper analyzes cell-type specific DNA methylation and transcriptomes in schizophrenia brains, finding reduced epigenetic distinction between cell types in schizophrenia.