GigaScienceBioinformaticsPeer-reviewed journal article
Loop detection using Hi-C data with HiCExplorer
Abstract
Chromatin loops are an important factor in the structural organization of the genome. The detection of chromatin loops in Hi-C interaction matrices is a challenging and compute intensive task. The presented approach shows a chromatin loop detection algorithm which applies a strict candidate selection based on continuous negative binomial distributions and performs a Wilcoxon rank-sum test to detect enriched Hi-C interactions.
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