Tom Sexton

The paper identifies a ten-gene transcriptomic signature from single-cell data that predicts prognosis and therapy response in triple-negative breast cancer.

The paper identifies SATB1's role in genome organization through direct binding to BURs, linking chromatin structure to cell type-specific gene expression.

The paper shows enhancers mediate euchromatin hopping, spreading euchromatin features to distal regions through chromatin looping, redefining enhancer identification using chromatin features.

This study investigates how NF-κB activation through HTLV-1 Tax reorganizes 3D chromatin to coordinate transcription and alternative splicing of target genes.

The paper investigates TAD remodeling during mouse thymocyte differentiation using Capture Hi-C, finding transcription can directly alter chromatin structure.

The paper shows that transcriptional control and chromatin architecture at the Sox2 locus are decoupled, with distinct regulatory mechanisms.

This study identifies mH2A1.1's role in regulating RNA Polymerase II paused genes through distinct chromatin mechanisms in breast cancer cells.

This paper introduces GP-FBM, a computational framework for analyzing chromatin diffusion dynamics, and shows similar diffusion properties in interphase and mitosis in mouse embryonic stem cells.

ChiCMaxima detects and visualizes chromatin loops in Capture Hi-C data using local maxima and a background model, showing improved robustness over existing tools.

The paper investigates how the Drosophila dosage compensation complex activates X chromosome genes through chromosome looping within the active compartment.