bioRxivBiophysics
Cryo-EM structure of the polycystin 2-l1 ion channel
Abstract
We report the near atomic resolution (3.1 [A]) of the polycystic kidney disease 2-like 1 (polycystin 2-l1) ion channel. Encoded by PKD2L1, polycystin 2-l1 is a calcium and monovalent cation-permeant ion channel in primary cilia and plasma membranes. The related primary cilium-specific polycystin-2 protein, encoded by PKD2, shares a high degree of sequence similarity, yet has distinct permeability characteristics. Here we show that these differences are reflected in the architecture of polycystin 2-l1.
Reproducibility ledger
Nobody has reported trying to reproduce this paper yet. Did you replicate an experiment or run the code? Your report saves the next lab a week.
Sign in to file a reproducibility report.
Related papers
- PKD2 is an essential ion channel subunit in the primary cilium of the renal collecting duct epithelium
X. Liu, T. Vien, … D. E. Clapham·bioRxiv·Nov 7, 2017
- Cytoplasmic tail of the putative polycystin channel Pkd2 regulates its clustering in the fission yeast eisosomes
- Ion channel function of polycystin-2/polycystin-1 heteromer revealed by structure-guided mutagenesis
Tobias Staudner, Juthamas Khamseekaew, … Alexandr V. Ilyaskin·FEBS LettersPeer-reviewed·May 12, 2025
- Defining the Polycystin Pharmacophore Through HTS & Computational Biophysics.
Eduardo Guadarrama, Carlos G. Vanoye, Paul G. DeCaen·bioRxiv·Jan 13, 2025
- Structural basis of lipid-mediated gating in a two-pore domain potassium channel
Fumiya K. Sano, Go Kasuya, … Osamu Nureki·bioRxiv·Nov 12, 2025
- ADPKD variants in the PKD2 pore helix cause structural collapse of the gate and distinct forms of channel dysfunction.
Orhi Esarte Palomero, Eduardo Guadarrama, Paul G. DeCaen·Proceedings of the National Academy of SciencesPeer-reviewed·Jun 12, 2025