Visual Analysis of Cell Death in Bladder Cancer -- A Bibliometrics-Based Comprehensive Study

Cell death mechanisms offer therapeutic strategies for bladder cancer, yet lack comprehensive bibliometric analysis. Map global research trends and hotspots in bladder cancer cell death mechanisms via bibliometrics. We analyzed 5,392 publications (1991-2024) from Web of Science using VOSviewer (co- authorship/keyword clustering), CiteSpace (citation bursts), and GraphPad Prism (statistics). Metrics included: (1) Temporal trends, (2) Country/institution contributions, (3) Journal impact, (4) Citation dynamics, (5) Collaboration networks, (6) Conceptual hotspots. China and the US led research output. Top institutions:University of Texas System (USA; 178 publications), UTMD Anderson Cancer Center (USA; 123), Nanjing Medical University (China; 122), Journal of Urology had the highest output (106 publications); Cancer Research (IF:12.5) the highest impact. Kim Wun-Jae was the most productive author (37 articles); Jemal A the most co-cited (446 citations). Keyword and citation analyses revealed emerging integration of cell death mechanisms with immunotherapy (IT) and photodynamic therapy (PDT) to overcome chemoresistance. This study delineates the evolution of bladder cancer cell death research and identifies IT/PDT as promising resistance-overcoming strategies grounded in targeted cell death pathways.