Connectal Coding: Discovering the Structures Linking Cognitive Phenotypes to Individual Histories
Joshua T VogelsteiniD, Eric BridgefordiD, Benjamin D. PedigoiD, Jaewon ChungiD, Keith Levin, Brett D. MenshiD, Carey E. PriebeiD
Abstract
Cognitive phenotypes characterize our memories, beliefs, skills, and preferences, and arise from our ancestral, developmental, and experiential histories. These histories are written into our brain structure through the building and modification of various brain circuits. Connectal coding, by way of analogy with neural coding, is the art, study, and practice of identifying the network structures that link cognitive phenomena to individual histories. We propose a formal statistical framework for connectal coding and demonstrate its utility in several applications spanning experimental modalities and phylogeny.
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