CSF complement proteins are associated with early tau pathology and synaptic damage in an asymptomatic population at risk of Alzheimer's disease
Julia Loncke, Mélissa Savard, Cynthia Picard, Henrik Zetterberg, Daniel S. Auld, Mohamed Badawy, Simon Ducharme, the Alzheimer’s Disease Neuroimaging Initiative, Sylvia Villeneuve, John C.S. Breitner, Judes Poirier
The paper investigates the association between CSF complement proteins and early AD pathology in at-risk individuals, finding C1q and Factor H linked to tau and synaptic markers.
bioRxiv · Aug 27, 2026 · PreprintNeuroscience