Nature NeuroscienceGeneticsPeer-reviewed journal article
Genome-wide association study of delay discounting in 23,217 adult research participants of European ancestry
Sandra Sanchez‐RoigeiD, Pierre FontanillasiD, Sarah L. ElsoniD, Anita PanditiD, Ellen M. SchmidtiD, Johanna R. Foerster, Gonçalo R. AbecasisiD, Joshua C. GrayiD, Harriet de WitiD, Lea Karatheodoris DavisiD, James MacKillopiD, Abraham A. PalmeriD
Abstract
Delay discounting (DD), which is the tendency to discount the value of delayed versus current rewards, is elevated in a constellation of diseases and behavioral conditions. We performed a genome-wide association study of DD using 23,127 research participants of European ancestry. The most significantly associated SNP was rs6528024 (P = 2.40 x 10-8), which is located in an intron of the gene GPM6B. We also showed that 12% of the variance in DD was accounted for by genotype, and that the genetic signature of DD overlapped with attention-deficit/hyperactivity disorder, schizophrenia, major depression, smoking, personality, cognition, and body weight.
- organism: human
- assay: GWAS summary statistics
- research focus: GWAS / association mapping
- approach: statistical model
- Citations
- 128
- FWCI
- 9.05
- Field percentile
- top 1%
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