Abraham A. Palmer

This paper expands the RatGTEx resource with transcriptome-wide associations across 3,160 RNA-seq samples, identifying 7,473 gene-trait links and 144,876 QTLs for 22,599 genes.

The paper replicates the association between St6galnac1 and Paraprevotella abundance in stool samples from non-fasted HS rats, confirming the association across different experimental conditions.

The paper uses Genomic SEM to identify loci underlying locomotor activity in rats, finding 31 loci compared to fewer from other methods.

The paper identifies non-SNP variants as significant regulators of gene expression and addiction-related traits in HS rats using joint cis-eQTL analysis.

The paper identifies genetic factors associated with balance in the elderly through GWAS and multimodal transcriptomic analysis of otolithic organs.

Trex-QTL identifies trans-eQTLs with global effects on molecular phenotypes, showing improved power and replicating known loci in rat brain data.

MetaboXcan predicts plasma metabolites from genetic data and associates them with complex traits, identifying disease risk genes and metabolites in chronic kidney disease.

LaDDR improves xQTL and GWAS discovery by generating latent RNA phenotypes without requiring complete gene annotations, outperforming existing knowledge-driven methods in multiple tissues.

This study performs a GWAS on cocaine self-administration in rats, identifying six genome-wide significant loci, including one linked to carboxylesterase genes involved in cocaine metabolism.

This study evaluates three deep learning models for optic nerve axon quantification on a novel rat dataset, finding reduced performance compared to published benchmarks.

The paper identifies genetic loci associated with anxiety-like and nociceptive traits in outbred Sprague-Dawley rats using genome-wide association analysis.

This study identifies sex-specific genetic loci and correlations for alcohol use behaviors and their comorbidities using genome-wide association studies.

This study shows that long-read genome sequencing improves detection of structural and repeat variants in autism and links them to functional consequences.

This study identifies 1,294 genomic regions and 961 effector genes associated with externalizing disorders, revealing neural mechanisms and polygenic predictors of variance in these conditions.

The paper identifies host genetic effects on microbiome composition in rats and finds evidence of indirect genetic effects contributing to missing heritability.

This study identifies sex-specific transcriptional changes in the SCN of rats during oxycodone withdrawal and abstinence, linking these changes to addiction-related behaviors.

This study shows ivermectin reduces alcohol intake during withdrawal by enhancing GABAergic inhibition in the CeA, specifically in rats with high P2rx4 expression.

This paper conducts GWAS on cannabis use frequency and lifetime use, identifies genetic loci, and shows genetic correlations with other traits and diseases.

The paper establishes an Alcohol BioBank using genetically diverse HS rats to study AUD, providing samples for genomic, transcriptomic, and proteomic analyses.

The paper investigates the functional role of recursive splicing in CADM2, showing that its deletion leads to altered gene expression and behavioral changes in neurodevelopmental disorders.

This study shows that perinatal fentanyl exposure in rats leads to long-term addiction risk and central amygdala gene dysregulation, providing insights into the molecular mechanisms of NOWS and its consequences.

The paper identifies three latent genetic factors of impulsivity and risk-taking traits and links them to distinct brain structures and developmental patterns in children.

RatXcan extends transcriptome-wide association studies to rats, enabling cross-species integration of GWAS and gene expression data to identify shared genetic mechanisms of complex traits.

This study finds that irregular estrous cycles in HS rats are associated with severe cocaine addiction-like behaviors, but estrous phase itself does not influence cocaine self-administration.

This study identifies genomic loci associated with cue-reactivity in rats, linking them to incentive salience and drug abuse-related traits.

This study identifies genetic loci associated with opioid use disorder-related behaviors in rats using a genome-wide association approach and network-based clustering.

This study uses a non-linear clustering approach in rats to identify distinct behavioral and neuronal profiles associated with heroin vulnerability and resiliency, reflecting human opioid use disorder heterogeneity.

This study investigates whether GLO1 inhibition affects cocaine or oxycodone-induced locomotor activity and conditioned place preference, finding no significant effects.

The paper describes a cost-effective, high-throughput genotyping method for heterogeneous stock rats using low-coverage sequencing data, achieving high accuracy comparable to high-coverage sequencing.