Richard Anney

Sub-diagnostic effects of genetic variants associated with autism

The paper maps the odds ratio for autism associated with rare LoF variants in autism-associated genes and shows sub-diagnostic effects in undiagnosed individuals.

Longitudinally stable, brain-based predictive models mediate the relationships between childhood cognition and socio-demographic, psychological and genetic factors

The paper develops brain-based predictive models for childhood cognition using multimodal MRI data from the ABCD study, showing stability over time and partial mediation of socio-demographic, psychological, and genetic factors.

Investigating regions of shared genetic variation in attention deficit/hyperactivity disorder and major depressive disorder: A GWAS meta-analysis

This study identifies 14 genome-wide significant SNPs associated with both ADHD and MDD, revealing novel genetic regions linked to their shared variation.

Identifying genetic variants associated with cerebellar volume in 33,265 individuals from the UK-Biobank

This study identifies 33 genome-wide significant SNPs associated with cerebellar volume in 33,265 UK-Biobank participants, highlighting 21 candidate genes and genetic correlations with other brain structures.

Using genetics to examine a general liability to childhood psychopathology

The paper examines whether genetic liability to schizophrenia and ADHD contributes to shared risks across childhood psychiatric diagnoses through a general psychopathology factor.

Novel Insight into the Aetiology of Autism Spectrum Disorder Gained by Integrating Expression Data with Genome-wide Association Statistics

This study integrates ASD GWAS summary statistics with gene expression data to identify differentially expressed genes in ASD and estimate heritability explained by predicted expression.

Sex differences in gene expression in the human fetal brain

The paper analyzes RNA sequencing data from human fetal brains to identify sex-biased gene expression, finding differences in 2558 autosomal and 155 X-chromosome genes, with implications for neurodevelopmental disorders.

Common risk variants identified in autism spectrum disorder

This study identifies five genome-wide significant loci and seven shared with other traits in a large ASD GWAS, highlighting polygenic heterogeneity and the value of large-scale GWAS in ASD.

Genome wide meta-analysis identifies genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders.

Cross-disorder meta-analysis of eight psychiatric GWAS (232,964 cases, 494,162 controls) reports 109 loci shared by two or more disorders and three groups of correlated disorders.

Low-frequency variation in TP53 has large effects on head circumference and intracranial volume

The paper identifies 9 novel genetic loci, including low-frequency variants in TP53, associated with head circumference and intracranial volume in up to 46,000 individuals.

Large-scale exome sequencing study implicates both developmental and functional changes in the neurobiology of autism

This study identifies 99 genes associated with autism spectrum disorder through large-scale exome sequencing, showing differences in mutation frequencies between ASD and severe neurodevelopmental delay groups.

ASD Diagnosis in Adults: Phenotype and Genotype Findings from a Clinically-derived Cohort

This study examines phenotypic and genetic characteristics of adults diagnosed with ASD, finding high psychiatric comorbidity and increased polygenic risk for common ASD variants.

A genetic investigation of sex bias in the prevalence of attention deficit hyperactivity disorder

This study investigates genetic mechanisms underlying sex bias in ADHD prevalence using genome-wide data and finds no mean polygenic burden difference across sexes but increased risk in female siblings and comorbid conditions.

Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders

The paper uses polygenic transmission disequilibrium to show common and rare variants act additively in autism risk, with polygenic risk over-transmitted to ASD cases but not unaffected siblings.