Spike-to-excite: photosensitive seizures in biologically-realistic spiking neural networks

Abstract

Photosensitive Epilepsy (PE) is a neurological disorder characterized by seizures triggered by harmful visual stimuli, such as flashing lights and high-contrast patterns. The mechanisms underlying PE remain poorly understood, and to date, no computational model has captured the phenomena associated with this condition. Biologically detailed spiking networks trained for efficient prediction of natural scenes have been shown to capture V1-like characteristics. Here, we show that these models display seizure-like activity in response to harmful stimuli while retaining healthy responses to non-provocative stimuli when post-synaptic inhibitory connections are weakened. Notably, our adapted model resembles the motion tuning and contrast gain responses of excitatory V1 neurons in mice with optogenetically reduced inhibitory activity. We offer testable predictions underlying the pathophysiology of PE by exploring how reduced inhibition leads to seizure-like activity. Finally, we show that artificially injecting pulsating input current into the model units prevents seizure-like activity and restores baseline function. In summary, we present a model of PE that offers new insights to understand and treat this condition.