Adam M. Packer

This study shows that two-photon imaging at 920 nm during optogenetic stimulation increases opsin desensitization in C1V1-expressing neurons, affecting both targeted and non-targeted cells.

This study investigates the claustrum's role in modulating prefrontal cortex neuronal activity, finding it enhances variability and network homogeneity through optogenetic stimulation and silencing.

The paper identifies distinct spatial and projection-based encoding of economic variables in the frontal cortex of mice during decision-making tasks.

This study shows that perinatal serotonin signalling affects cortical GABAergic circuit development, leading to lifelong sensory encoding changes.

The paper identifies a pool of non-coding neurons in the barrel cortex that can be recruited to enhance perception through optogenetic activation during sensory tasks.

The paper introduces a test to assess the relevance of trial-averaged neuronal metrics to neuronal computation, finding they are less relevant in less controlled settings.

This protocol provides standardised measurements to assess and compare multiphoton microscope performance across users.

This paper delineates four subregions within the mouse claustrum complex using fiber-architecture, genetic markers, and connectivity data, providing a reference framework for future studies.

This paper investigates the factors affecting spatial precision in two-photon optogenetic photostimulation and finds that optical resolution is not the limiting factor.

The paper investigates excitability during seizure propagation in the brain, finding that single-cell excitability remains baseline while local inhibition occurs near the seizure wavefront.

This study determines the developmental timeline of the mouse claustrum, including neuronal birthdates, spatial localization, and the maturation of its cortical projections.

This study identifies claustrum neurons and their connectivity patterns, showing they integrate inputs from multiple cortical regions and contribute to multimodal sensory processing.

This paper describes an experimental protocol for all-optical interrogation of neural circuits in behaving mice, demonstrating its application in three brain areas.

The paper investigates how neural variability in the somatosensory cortex affects the perception and propagation of activity between brain regions in mice.

The paper shows that visual cortex activity influences perception, but this effect depends on task difficulty and network connectivity patterns.

The paper introduces two open-source tools, PackIO and EphysViewer, for synchronizing and analyzing neuroscience data across multiple devices.