Taufik A. Valiante

Stimulus-specific recruitment of human amygdala neurons predicts episodic memory encoding success

The paper shows that specific amygdala neurons in humans fire more during encoding of items later remembered, predicting episodic memory success, particularly in the right amygdala.

Cellular code for mnemonic pattern separation in the human hippocampus is revealed by false memories

The paper identifies memory selective neurons in the human hippocampus that correlate with pattern separation and show behavioral relevance in episodic memory.

Criterion-selective neurons in the human medial frontal cortex track decision thresholds during memory-based decision making

The paper identifies two types of neurons in the medial frontal cortex that track decision criteria and memory strength during memory-based decision making.

Laser-integrated nanophotonic neural probes with on-chip sensors for addressable photostimulation

This paper develops laser-integrated nanophotonic neural probes with on-chip sensors for scalable photostimulation and feedback monitoring in optogenetic experiments.

Activating Ras-MAPK pathway variants drive hippocampal clonal competition in human epilepsy

This study identifies somatic Ras-MAPK pathway variants in hippocampal tissue from patients with drug-resistant epilepsy, showing their association with clonal competition and worse surgical outcomes.

Intrinsic plasticity underlies malleability of neural network heterogeneity

The paper investigates how intrinsic plasticity influences neural network heterogeneity by analyzing input statistics and their effects on cell-to-cell excitability and network dynamics.

Time Cells in the Human Brain Support Working Memory Maintenance

The paper identifies time cells in the human brain that support working memory by forming sequences encoding time and memory content during WM maintenance.

Order-Selective Cells Tile Temporal Space and Predict Order Memory in Humans

The paper identifies order-selective cells in the human brain that represent temporal order during memory encoding and retrieval, predicting memory accuracy.

Nanophotonic neural probes for in vivo photostimulation, electrophysiology, and microfluidic delivery

This paper introduces multifunctional nanophotonic neural probes that combine photostimulation, electrophysiology, and microfluidic delivery for in vivo use in mice.

Disrupting selective persistent activity with electrical stimulation impairs human working memory

This study shows that disrupting selective persistent neural activity in the hippocampus and ventral temporal cortex with electrical stimulation impairs human working memory performance.

H- and m-channel overexpression promotes seizure-like events by impairing the ability of inhibitory neurons to process correlated inputs

This study identifies a mechanism by which h- and m-channel overexpression leads to seizure-like events through impaired processing of correlated inputs in inhibitory neurons, independent of changes in the excitatory-inhibitory balance.

Hyperpolarization-activated cation channel mediated intrinsic plasticity changes underlie the malleability of with-in cell-type electrophysiological heterogeneity

The paper shows that within-cell-type electrophysiological heterogeneity is malleable and can be restored by blocking HCN currents in epilepsy models.

On the relationship between neuronal heterogeneity and entropy

The paper shows that entropy of neuronal size distributions depends on variance, not absolute size, using total dendritic length across species.

EEG biomarkers of α5-GABA positive allosteric modulators in rodents

This study identifies distinct EEG biomarkers for 5-PAM in rodents, showing specific changes in theta and beta/gamma power compared to diazepam.

Persistent activity during working memory maintenance predicts long-term memory formation in the human hippocampus

This study shows that persistent hippocampal activity during working memory maintenance predicts long-term memory formation in humans.

Neural dynamics underlying minute-timescale persistent behavior in the human brain

This study investigates how the human medial frontal cortex and hippocampus encode task context over time, revealing distinct coding strategies for maintaining and switching task sets.

Control of working memory maintenance by theta-gamma phase amplitude coupling of human hippocampal neurons

This study investigates how theta-gamma phase amplitude coupling in the hippocampus supports working memory by integrating cognitive control and improving memory fidelity.

Precise Timing Matters: Modulating Human Memory by Synchronizing Hippocampal Stimulation to Saccadic Event Related Potentials

This study shows that precise hippocampal stimulation timed to saccadic ERPs enhances memory, while random or early stimulation impairs it, challenging rodent theta rhythm assumptions.

In-silico testing of new pharmacology for restoring inhibition and human cortical function in depression

The paper models the effects of 5-PAM on human cortical microcircuits to assess its potential in treating depression and identifies EEG biomarkers for drug efficacy.

Abstract representations emerge in human hippocampal neurons during inference behavior

The paper shows that human hippocampal neurons form abstract, disentangled representations during inferential reasoning tasks, which correlate with inference behavior.

Hyperpolarization-activated cation channels shape the spiking frequency preference of human cortical layer 5 pyramidal neurons

The paper investigates the role of hyperpolarization-activated currents in shaping spiking frequency preference of human cortical layer 5 neurons using computational models and experimental validation.

Intrinsic neural diversity quenches the dynamic volatility of neural networks

This study shows that excitability heterogeneity in neural networks enhances resilience by reducing dynamic volatility and making the system independent of control parameters.

Hippocampal Theta Phase Precession Supports Memory Formation and Retrieval of Naturalistic Experience in Humans

This study shows that phase precession in human hippocampal theta oscillations correlates with memory encoding and retrieval success during naturalistic experiences.

All-optical interrogation of excitability during seizure propagation reveals high local inhibition amidst baseline excitability

The paper investigates excitability during seizure propagation in the brain, finding that single-cell excitability remains baseline while local inhibition occurs near the seizure wavefront.

Age-dependent increased sag amplitude in human pyramidal neurons dampens baseline cortical activity

The paper identifies age-related increases in sag voltage amplitude in human pyramidal neurons and shows reduced baseline firing in older neuron microcircuits.

A corollary discharge mediates saccade related inhibition of single units in mnemonic structures of the human brain

The paper investigates how saccadic eye movements modulate single-unit activity in the human mesial temporal lobe and identifies a corollary discharge-like signal associated with these movements.

Inter-regional delays fluctuate in the human cerebral cortex

The paper shows that low-frequency oscillations in the human cerebral cortex are linked to delayed inter-regional couplings during auditory tasks.

Seizure localisation with attention-based graph neural networks

This paper introduces a graph neural network with attention mechanism to localise seizure onset zones in epilepsy patients using intracranial EEG data, showing strong correlation with clinical reports.

Resilience through diversity: Loss of neuronal heterogeneity in epileptogenic human tissue impairs network resilience to sudden changes in synchrony

The paper shows that reduced neuronal heterogeneity in epileptogenic tissue decreases network resilience to synchrony changes, leading to seizure-like dynamics.

Cognitive boundary signals in the human medial temporal lobe shape episodic memory representation

This study identifies neurons in the human medial temporal lobe that signal cognitive boundaries between episodic events and shows these signals correlate with memory accuracy and temporal order recall.