Cell Maps for Artificial Intelligence: AI-Ready Maps of Human Cell Architecture from Disease-Relevant Cell Lines

Timothy Clark; Jillian Mohan; Leah V. Schaffer; Kirsten Obernier; Sadnan Al Manir; Christopher Churas; Amir Dailamy; Yesh Doctor; Antoine Forget; Jan N. Hansen; Mengzhou Hu; Joanna Lenkiewicz; Maxwell Adam Levinson; Charlotte A Marquez; Sami Nourreddine; Justin C. Niestroy; Dexter R. Pratt; Gege Qian; Swathi Thaker; Jean‐Christophe Bélisle‐Pipon; Cynthia Brandt; Jake Y. Chen; Ying Ding; Samah Jamal Fodeh; Nevan J. Krogan; Emma K. Lundberg; Prashant Mali; Pamela Payne‐Foster; Sarah J. Ratcliffe; Vardit Ravitsky

doi:10.1101/2024.05.21.589311

Systems BiologybioRxivMay 21, 2024

Preprint

Cell Maps for Artificial Intelligence: AI-Ready Maps of Human Cell Architecture from Disease-Relevant Cell Lines

Timothy Clark iD, Jillian Mohan, Leah V. Schaffer iD, Kirsten Obernier iD, Sadnan Al Manir iD, Christopher Churas iD, Amir Dailamy iD, Yesh Doctor iD, Antoine Forget iD, Jan N. Hansen iD, Mengzhou Hu iD, Joanna Lenkiewicz iD, Maxwell Adam Levinson iD, Charlotte A Marquez iD, Sami Nourreddine iD, Justin C. Niestroy iD, Dexter R. Pratt iD, Gege Qian iD, Swathi Thaker iD, Jean‐Christophe Bélisle‐Pipon iD, Cynthia Brandt iD, Jake Y. Chen iD, Ying Ding iD, Samah Jamal Fodeh iD, Nevan J. Krogan iD, , Trey E. Ideker iD

Abstract

This article describes the Cell Maps for Artificial Intelligence (CM4AI) project and its goals, methods, standards, current datasets, software tools, status, and future directions. CM4AI is the Functional Genomics Data Generation Project in the U.S. National Institute of Healths (NIH) Bridge2AI program. Its overarching mission is to produce ethical, AI-ready datasets of cell architecture, inferred from multimodal data collected for human cell lines, to enable transformative biomedical AI research.

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