Alex Khang

This paper harmonizes 2D and 3D immunofluorescent cell shape datasets using generative AI to create synthetic cells for machine learning and in silico studies.

This study shows that nuclear mechanics influence intestinal stem cell differentiation by sensing tissue shape and modulating lamin-A levels.

This study shows PTEN suppresses myofibroblast activation in valvular interstitial cells by promoting quiescence and reducing stiffness-induced activation.

The paper develops mathematical descriptors to quantify fibroblast phenotypes and validates them using drug-treated cells to predict myofibroblast activation.

This study uses bottlebrush polymer hydrogels to show how strain-stiffening affects hMSC protrusion formation and mechanosensing.